Frédéric Thomas (director)
Frédéric Thomas is the Directeur de Recherche (senior scientist,) at CNRS. He has a well-established expertise in the field of host–parasite interactions, especially host manipulation. He has published more than 190 articles in international peer-reviewed journals (1995–present), including Nature, Evolution, Trends in Ecology and Evolution, Ecology Letters, Ecology, American Naturalist, Proceedings of the Royal Society, PLOS pathogen, and Proteomics, and he also edited 10 books (3 at Oxford University Press). He has been working on projects related to evolution and cancer since July 2011 and has since published 19 articles on this topic (e.g., Biology Letters, Evolutionary Applications, BMC Cancer, Infection Genetics and Evolution, Evolution).
Benjamin Roche (co-director)
Benjamin Roche is Chargé de Recherche (junior scientist) at IRD (Research Institute for Development). Combining a solid background in computing sciences/biomathematics and a PhD in ecology and evolutionary biology, his research has focused mainly on the relationship between biodiversity and infectious disease transmission from both a theoretical and an empirical perspective. Since the beginning of his research career (2008), he has published 22 papers in international peer-reviewed journals, including Trends in Ecology and Evolution, Ecology Letters, American Naturalist, Philosophical Transactions of the Royal Society, PLOS Biology, and BMC Bioinformatics. He has been involved in projects related to evolution and cancer since July 2010, especially on Peto’s paradox and the role of immune system dynamics on the accumulation of cancerous cells.
Frederic Mery is Chargé de recherche (junior scientist) at CNRS and manages a team (Evolution and Plasticity of Cognitive Capacities) at EGCE (Laboratory Evolution Genomes Behavior and Ecology) on the campus Paris-Saclay. He is using the Drosophila biological model to investigate how social interactions may affect individual behaviors and physiology and how these interactions impact evolutionary processes. He has published more than 40 scientific papers in journal such as Science, Evolution, Current biology, Proceedings of the Royal Society, Animal Behavior... Within the CREEC, he is particularly interested in the impact of social environment on the dynamic of cancer progression.
Jacques Montagne is Directeur de Recherche at CNRS and works at I2BC (Institute of Integrative Biology of the Cell) in the Paris-Saclay campus. His research team is using the Drosophila model system to investigate the links between cell growth and metabolism. He contributed to the pioneer work showing that the signalling pathways that integrate insulin and nutrient responses are conserved in Drosophila and control cell growth. He is using a combination of genetic, imaging and biochemical approaches to evaluate the effect induced by perturbations of lipid metabolism and nutrition on cell growth. He is focusing on both developmental and genetically-deregulated processes to mimics pathologic situation including cancers and metabolic syndrome.
Marion Vittecoq is a researcher at the Tour du Valat Research Centre (see more). She has an expertise in health ecology and wildlife diseases. She obtained her PhD in biology in 2012 following her work on emerging infectious diseases in the Mediterranean wetlands in the context of global changes. Since the beginning of her PhD thesis, she has published 10 articles in peer-reviewed journals including Trends in Ecology and Evolution, Biology Letters, and PLOS One. She has been involved in projects developed at CREEC since 2011. She is particularly interested in the link between infectious diseases and cancers and in the role that oncogenic phenomena can play in ecosystem functioning and wildlife species dynamics.
François Renaud works on genetic interactions between hosts and pathogens, especially human parasites. He is assistant director of the MIVEGEC laboratory, and he is particularly interested in the evolutionary biology of pathogens that infect humans and primates. He is currently developing research projects on the ecology and evolution of prokaryote communities that live in physiological ecosystems, especially the human body. He has published more than 170 articles in international peer-reviewed journals including Nature, PNAS, The Lancet, TREE, Ecology Letters, and PLOS pathogens, and has edited several books on the evolutionary ecology of host–parasite relationships. He has also participated in the training of several foreign research scientists (Spain, Thailand, Gabon, Senegal) on the evolutionary biology of pathogens.
Dorothée Misse (PhD, HDR) is Chargé de Recherche and works on the pathogenesis of emerging viruses with a focus on factors induced by virus–host interactions. Working on a number of infectious agents including HIV-1, DENV, CHIKV, HCV, HBV, and the H5N1 virus has given her a broad understanding of viral infection. She directed the TVE (Transmission des Virus Emergents) group. She has recently been involved in research on the infectious causes of certain cancers. She teaches courses in virology for the “Dynamics of Parasite–Host–Environment Interactions” Master’s Degree program. She is a member of the French Society for Immunology. She has acted as principal investigator in many externally funded projects (e.g., SIDACTION, ANRS, ANR BLANC). This work has led to several publications (e.g., in Nature Biotechnology, PLOS Pathogens, Trends in Ecology and Evolution, Blood, EMBO Reports, Proteomics), five patents, and two books.
Eric Elguero is research engineer at IRD. He was trained in mathematics and earned a doctorate in statistics. He has experience in several domains, including botany, hydrology, and more recently epidemiology and population genetics. The projects he has worked on recently are in the fields of vaccine safety, evolution of the malaria agent, and cancer epidemiology.
Florence Bernex is a Chargé de Recherche (scientist, senior pathologist) working at both CNRS and the Experimental Histology Network of Montpellier (RHEM: Réseau d'Histologie Expérimentale de Montpellier). She has a well-established expertise as a veterinary pathologist dedicated to research, notably on genetically engineered mice as models of human diseases; her research interests include developmental biology and cancer. She has published 44 articles in international peer-reviewed journals (1992–present), including Development, Oncogene, Developmental Biology, Mechanisms of Development, PNAS, Gastroenterology & Molecular Cell. She has been working on projects related to cancer since 1997, and since then has published 13 articles on this topic in Oncogene, Molecular Cancer, Pigment Cell Melanoma Research, and Molecular Cell. She has been Assistant Professor at the Alfort National Veterinary School near Paris since 1996 and moved to Montpellier in 2011. She has been working at CNRS and RHEM since January 2012, where she conducts histopathological analyses, mostly on virtual slides. She has been involved in the Peto's paradox project with Frédéric Thomas's team since November 2012. She is particularly interested in cancer stem cells and in the evolution of dormant cancer cells with time.
Nelly Pirot is a research engineer at INSERM–IRCM (Cancer Research Institute of Montpellier). She is technical manager of a group within the Experimental Histology Network of Montpellier (known as RHEM, Réseau d'Histologie Expérimentale de Montpellier), and she manages the histology core facility at IRCM. She has expertise in many fields, including experimental necropsy, histology, tissue micro-array, immunohistochemistry, and virtual slide imaging. She works on various mouse models of human cancer that were obtained by transgenesis, gene targeting, injection of tumoral cell lines, or graft of a patient's tumor to mice (the Patient Derived Xenograft model). She obtained her PhD in biology in 2009 following her work on the role of a transcription factor in angiogenesis and lymphangiogenesis in transgenic mice. Since the beginning of her PhD thesis, she has published six articles in peer-reviewed journals, including Blood, PNAS, and PLOS One. She offers her expertise to different research projects mainly dedicated to the study of mice models of cancer. She has been involved in the Peto's paradox project with Frédéric Thomas's team since November 2012.
Nathalie Barougier is Technicienne de classe exceptionnelle working at IRD and she is responsible for the centre’s animal care facility. She has expertise in animal experimentation (Niveau 1 ENVT 2007) and experimental surgery (Université Clermont Ferrand 2008). She is also involved in different animal care facilities in Montpellier (RAM) (France).
Pascal Boutinaud is responsible for the IRD experimental structure in Montpellier. He has a Master’s Degree in biology (Montpellier), another in the management of natural resources (ENSA Rennes), and more recently completed one in physiology and neurosciences (Lyon). He oversees all of the experimental procedures with respect to their accordance with legislation and ethics rules. He is also involved in local committees and acts as an expert for different projects and training of IRD partners.
Dominique Faugère is technician at CNRS since 3 years. Before this, she worked 22 yes at Centre Hospitalier Régional Universitaire (CHRU) in Montpellier, in a cancerology department. She is now involved in all the CREEC’s projects, especially those involving drosophila.
They were part of the CREEC team:
Déborah Garcia is technician at IRD. She obtained a Master’s Degree in cellular and molecular endocrinology; during this period, she also studied cancerology with a team working on tumorigenesis in endocrine glands. Since she began working at IRD, she has applied her competence and knowledge to the study of host–parasite systems and microbiology. Her expertise extends from cellular and molecular biology to biochemistry and animal experimentation. She is regularly involved as a coauthor in publications as well as pharmacological patents.